This paper establishes calculation models of four multilayer frame structures based on the multispring rod unit, in the light of the influence of cast-in-place slab on the hysteretic dissipative energy distribution of concrete frame structure members. The target structures include a rectangular beam model, a rectangular beam model with consideration of reinforced stiffness, a rectangular beam model with consideration of reinforced strength and a T-beam model with consideration of the flange slab. The paper also describes the hysteretic dissipative energy distribution on structure under rare occurrence earthquake of 8.0 seismic fortification intensity for comparative analysis. The calculation results show that, with the increase of beam strength, the total hysteretic dissipative energy on structure increases while the ratio of the dissipative energy of beam to the total dissipative energy decreases; and with the increase of beam stiffness, the total hysteretic dissipative energy on structure increases and the ratio of the dissipative energy of beam to the total dissipative energy also increases. With consideration of the effect of slab flange, the increase of T-beam strength obviously influences the distribution of dissipative energy on each layer and between beams and column members. The increase of beam stiffness makes sudden change on the distribution of hysteretic dissipative energy. The hysteretic dissipative energy of an inner beam on each layer is less than that of an outer beam and the hysteretic dissipative energy of a side column is less than that of a center column. The evolution course of plastic hinge reflects the transfer of dissipative energy of structure. Under the action of flange slab, the structure is damaged in the pillar-hinge manner instead of the original beam-hinge manner, proving that the influence of the slab flange on the dissipative energy of structure cannot be ignored.