A valve-less gas piezoelectric pump based on synthetic is designed for continuous flow and the output flow rate increasing. First, the working principle of the gas piezoelectric pump is presented and the amplitude of the piezoelectric vibrator is measured. Then, the distribution of gas velocity at different moments (for 0T，0.25T, 0.5T，0.75T) is obtained by simulation analysis of the valve-less gas piezoelectric pump with CFX software. Besides, the influences on the pump flow from the cavity height, pump cavity height, jet orifice diameter and outlet diameter are studied. Finally, the experimental prototype of valve-less gas piezoelectric pump is fabricated. The valve-less gas piezoelectric pump has the cavity height of 0.1 mm, the pump cavity height of 1.4 mm, the jet orifice diameter of 1.3 mm, and the outlet diameter of 2.0 mm. When driven at a voltage of 120 V,400 Hz, the output flow is 1 800 ml/min. The experimental results agree with those of the simulation. The pump increases the gas flow, and is able to continuously output flow.