In order to thoroughly solve the problem of severe vibration in the pipeline system of high-pressure gas distribution room and ensure the smooth development of subsequent major model test tasks， a variety of numerical simulation methods and test methods are combined to carry out structural vibration analysis and vibration suppression research. Firstly， based on the finite volume method the aerodynamics numerical model of the flow field in the pipeline system is constructed， and then the dynamic loads of airflow applied on the pipeline structure is calculated and extracted. Secondly， based on the finite element method the structural dynamics numerical model of the pipeline system is established， which is used to analyze the modal characteristics. Finally， combining the above two numerical models， the structural vibration response of pipeline system is calculated， and the corresponding vibration suppression mechanism is developed according to the results. The comprehensive analysis method fully clarifies the basic causes of vibration， and lays a solid foundation for vibration suppression. After vibration suppression， the structural vibration is greatly reduced， which fully has the ability of continuous work. The research results show that the vibration research method can be used to guide the structural design or technical transformation of high-pressure and high-speed fluid pipeline， and can also be used to guide the development of aerodynamic test equipment.