The complex marine environment factors such as current，temperature and pressure can interfere with the normal operation of micro-electro-mechanical system （MEMS） vector hydrophone and affect its ability to pick up weak acoustic signals. Firstly， a "sandwich" type anti-current packaging structure mathematical model is established，and the effect of different anti-current structure parameters on ocean current noise suppression is obtained through simulation. Secondly，the effects of sea water temperature and water depth （hydrostatic pressure） on the sensitivity of MEMS vector hydrophone are simulated by Comsol software. Finally， the experimental results show that the sandwich encapsulating structure can suppress the flow noise more than 20 dB. The sensitivity variation of MEMS vector hydrophone is less than ±0.5 dB in the range of 0~40 °C seawater temperature and less than ±0.9 dB in the range of 0~12 MPa hydrostatic pressure， which is basically consistent with the theoretical analysis and simulation results.