By analyzing the advantages and potential of wireless sensor networks (WSN), the WSN applied to machinery equipment condition monitoring is proposed to compensate for the limitations of current wired connection machinery equipment condition monitoring systems. Aiming at the issues existing in machinery equipment condition monitoring for WSN node, those problems are the low hardware performance, the low sampling frequency, the lack of research on signal synchronous acquisition, the few studies on fast and reliable transmission of large amounts of data, the difficult which is to achieve the machine vibrations that reflect the most critical information of machinery equipment conditions, etc. To realize the machinery equipment condition monitoring based on WSN, it is necessary to solve problems like the high speed synchronous acquisition, real-time and reliable data transmission, energy supply, etc. Finally the low cost, low power consumption, miniaturization, networking, multifunction would be the development direction of WSN in machinery equipment condition monitoring applications.