By taking a piezoelectric smart flexible structure as the experimental model to simulate the solar panel substrate, the FXLMS algorithm based MIMO adap tive vibration control of piezoelectric flexible structure was studied consideri ng the active vibration control requirements for the structure vibration response. Multi-channel adaptive filtered feedforward control algorithm and its FXLMS a lgorithm process were analyzed as well as the model parameter identification str ategy for the controlled structure with the controller structure diagram. Aimed at design of the experimental model, structure modal charact eristic analysis, optimal placement for piezoelectric patches, development of ex perimental platform, the measurement and control platform for related software a nd hardware, experimental process description, and result analysis verification, the research methods were described and the multi channel active vibration con tr ol experiment was conducted. The result shows that the controller structure design and the adaptive algorithm are effective, thus it provides references to the distributed multi-channel vibration control of space flexible structures.