The design of fixture is comprehensive work whose performance has a great influence upon the vibration test. Topology optimization and parameters optimization are proposed to solve the problems of low vibration frequency, poor transfer characteristics and much energy consumption faced with fixture design. In accordance with actual application and the design principles of the fixture, topology optimization forms the reasonable general layout of the fixture, and parameter optimization adjusts the geometric parameters of it, in which way comes the fixture satisfying the design requirements. This paper takes some kind of fixture for example and takes FEM analysis software Patran／Nastran as the platform of simulation and analysis. In the way of designing and improving the fixture using topology optimization and parameters optimization in turn, the fixture meeting the requirement is derived, whose validity is verified by the experiment. The way proposed by this paper is also valuable to the dynamic design of other structures.