基于Photoplethysmography和弹性常数的动脉弹性检测方法
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R318.6; R331

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国家自然科学基金资助项目(81371713);中央高校基本科研业务费资助项目(CQDXWL2012 127)


The Detection of Arterial Elasticity Based on Photoplethysmography and Elastic Constant
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    摘要:

    针对目前无创动脉弹性检测存在检测费时,操作不便的问题,研究一种基于光电容积脉搏波描记法(photoplethysmography,简称PPG)和弹性常数评估糖尿病患者动脉弹性的检测方法。依据动脉径向振动的压力波方程和弹簧常数模型推导出评估动脉弹性的弹性常数,研究弹性常数与臂踝脉搏波传播速度(brachial ankle pulse wave velocity,简称baPWV)的相关性。统计分析结果表明,基于PPG和桡动脉搏波的弹性常数具有明显的相关关系(p<0.001,r=0.85)。baPWV和基于PPG的弹性常数具有明显的负相关关系(p<0.001,r=-0.701);多元回归分析同样表示两者明显相关。此外,用t检验研究实验组和对照组之间弹性常数的差异;P<0.05表明两组之间的差异有统计学意义。基于PPG的弹性常数法可以有效区分实验组和对照组的动脉弹性特征,是一种快速、有效的动脉弹性检测方法

    Abstract:

    In order to improve the time-consuming and inconvenient operation of measuring arterial elasticity, an arterial elasticity measurement for diabetic patients is developed that uses the elastic constant based on photoplethysmography (PPG).As the artery vibrates in a radial direction, the elastic constant used for evaluating peripheral arterial elasticity can be derived based on the arterial pressure wave equation and the spring constant model. In addition, the relationship between the elastic constant and the brachial-ankle pulse wave velocity (baPWV) is investigated. The results of the statistical analysis indicate a significantly high correlation between the elastic constants computed by PPG and the radial pulse (p<0.001, correlation coefficient=0.85). The results also indicate a significant negative correlation between the baPWV and the elastic constant based on PPG (p<0.001, correlation coefficient =-0.701). Multivariate regression analysis also indicates a close relationship between them. In addition, the Student′s t test is used to examine the difference of the elastic constant computed by PPG between the experimental and control groups. A p-value less than 0.05 indicates that the difference between the two groups is statistically significant. These results suggest that the elastic constant based on PPG can effectively identify the characteristics of arterial elasticity between the experimental group and the control group, and that arterial elasticity can be measured quickly and effectively.

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  • 在线发布日期: 2014-11-14
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