In this paper, a test bed of the multi-rotor bearing system is established for coupling misalignment, and the dynamic behaviors and vibration mechanisms of the system with parallel and angular misalignments are focused on. The experimental results show that fequancy multiplication in the steady-state responses of the rotor system with misalignments increases when accelerating. At low speeds, the motions of the rotor orbit showsynchronous vibration characteristics. With increasing speed, the orbit shows the shape of an “8”, or polycyclic oval, and the orbit curvatures in some positions change greatly. Moreover, for the parallel misaligned rotor system, the summation and difference of the harmonic waves appeas at higher speed.