The dynamic response characteristics and mechanical process subjected to impact load are investigated, based on the modal test, inclined impact test, and numerical simulation analysis of a K6-type single-layer reticulated dome. Experimental study on a large-scale reticulated dome model is also performed. Structural modal parameters are collected by a dynamic signal measurement and analysis system. The impact process, shell deformation and failure modes are photographed with a high-speed camera. The dynamic response time history data of key bars and key points are obtained using a dynamic strain gauge, displacement sensors and acceleration sensors. Results show that the modal test validates the the correctness of model. Response modes of the reticulated dome can be divided into three in the oblique impact test. The most unfavorable loading points are commonly the nodes farthest from the base subjected to inclined impact loads. The closer the position to the impact point, the sooner the response time, and the greater the response amplitude will be. The spread of response time from the impact area to the whole net shell is about 0.15~1.58ms. Results from dynamic response analysis of the impact test are similar to those of theoretical analysis.