The influence of the throttle motion on the air flow-induced noise process is studied. By applying the computational fluid dynamics (CFD) and computational aeroacoustics (CAA) coupling approach and the moving mesh technique, a 3-dimensional air transient flow and flow-induced noise process is simulated to realize the throttle quick-opening from the closed position to the fully open position. The principle of the air flow and flow-induced noise is analyzed when the throttle is opening at different rotation angle. At the beginning period of the throttle rotation, the vortex appears in the flow field behind the throttle, the pressure drops distinctly between the front and the back of the throttle, two flow-induced noise fields appear near the top and bottom position of the throttle and move towards the downstream and then merge gradually, the maximum value of the acoustic power level appears when the throttle rotation angle is opening near 40 degree, the flow-induced noise acoustic power level firstly increases and then decreases. With the opening angle increasing, the vortex is weaken and the value of pressure drop decreases between the two sides of the throttle. The time-frequency domain numerical simulation results fo the flow-induced noise show that during the throttle quick-opening process the flow-induced noise is mainly a kind of middle and low frequency broadband noise, the main part of the noise is frequency noise below about 100 Hz, the acoustic pressure is higher and does not reduce significantly with the increase of the distance between the measurement point and the throttle center. Reducing the low frequency noise plays a key role in the flow-induced noise control of the throttle.