In order to fully understand how effect of welding and annealing on deformation of frame, the systematic analysis and evaluation methods are proposed by taking 3D average deviation, 3D standard deviation and four corners of the height difference as the evaluation indexes, positioning the large frame as a whole with optical photogrammetric system, and quick acquitting data with laser scanner and processing point clouds data with Geomagic-studio software as well. Here design model is used as reference and a Geomagic-qualify software is used for deformation analysis and evaluation in welding and annealing processes. The research results show that the method above by combining 3D laser scanner with Geomagic can accurately and quickly measure and analyze the deformation of frame in production, which provides a new method for manufacturing quality monitoring. The error analysis indicates that the welding process is the main factor of frame deformation, and the contribution from annealing process is less than 0.58 mm in 3D average deviation. The research results provide a scientific basis to further save annealing time in frame manufacturing and lower the cost of production and energy down.