In order to realize the online monitoring of the working conditions of pipeline of pumping stations, and to ensure the operation of the pumping station safely and stably, a monitoring method based on permutation entropy algorithm for pressure pipeline of pumping station is proposed. This method can give full play to the advantage of permutation entropy algorithm including the simple calculation and the high sensitivity, which can reflect the small changes of the non-linear and non-stationary signal. It can obtain the vibration signal of the pipeline in the pumping station by arranging the sensors in the key parts, which determines the vibration state of the pumping station pipeline by the change of the subsequences entropy in vibration signal. The method of this paper is applied to monitor the operation of the seven pump station pipelines of Jingtai Project Phase II. By setting different operating conditions for instance verification, the results show that in the moment of switching unit the maximum amplitude error of vibration signal subsequence entropy reaches 0.37, and when the unit operate stably, it is only 0.07, this method has high accuracy and reliability in identifying the changes in operating state of the pump pipeline quickly and easily by the change of the entropy. A new idea for the online monitoring of the operating conditions of the pumping station pipeline and a basis for the structural safety diagnosis in the next step are provided by this method, which has good engineering practicability and popularization value.