In order to study the dynamic response of anti-dip layered rock slope models, one 2D physical model of anti-dip layered rock slope containing two groups of rock joints is designed for the shaking table test. The influence of different dynamic parameters including wave type, amplitude and frequency on the dynamic response of the slope model is considered. The research results reveal that the amplification coefficient of peak ground acceleration（PGA）increases with increasing the relative elevation, which is basically showed the non-linearly amplification characteristics, and this amplification trend is obvious near the slope top. With the increase of acceleration amplitude, PGA amplification coefficients rise on the whole, but it is influenced by rock structure and wave type. PGA amplification coefficients increase with the increase of frequency, and the growth trend become stronger near the slope top. The slope model under seismic loads mainly presents that shear cracks and tension cracks extend, connect and from step-type fractures. The failure of the slope is mainly caused by bending crack along joint surfaces. The study has theoretical and practical significance.