Vibration characteristics of cantilevered honeycomb sandwich panels with local damage are studied by use of electronic speckle pattern interferometry (ESPI). By comparing with the results of finite element modeling simulation on cantilevered aluminum plate, the viewpoint of the homogeneous characteristics of honeycomb sandwich structures can be verified. The first fourteen out-of-plane resonant mode shapes of an intact plate are obtained by experimental method. The experimental results show that comparing with those of intact one, resonant frequencies of the honeycomb sandwich panels will become lower with the structural damage appearance, and the resonant mode shapes also change with the damage location and orientation. Veering in the mode shapes can be observed when the damaged structures vibrate at higher order resonant modes.