In order to quantitatively evaluate the influence for rain load on aerodynamic force and wind effects of super large cooling towers, a 220m high (the highest in the world) indirect air hyperbolic cooling tower which is being built in domestic is taken as an example. Firstly, the wind field around the cooling tower is simulated based on computational fluid dynamics (CFD) method, and the strong rainstorm of 50 mm/h is also simulated by adding the discrete phase model (DPM) after the effectiveness is verified. Flow characteristics, characteristic value of wind and rain loads, change of mean pressure coefficient were systematically analyzed. On this basis, the stable performance and mechanical property of super large cooling tower are analyzed contrastively under simultaneous action of wind and rain with finite element method. Studies show that the total rain load of cooling tower surface is up to 6.71% of total wind load. Rain pressure coefficient can reach more than 0.07 in a particular area, and the ratio is even up to 26.98% compared with the wind pressure coefficient. Compared to the wind load, buckling stability and local stability of cooling tower are reduced and the inner force of drum, pillars and base of cooling tower are increased under simultaneous action of wind and rain. The maximum buckling displacement of cooling tower increased about 10%, and axial force of windward side increased about 17.4%. Main Conclusions can provide references for wind/rain loads design of such large cooling towers.