To study the regulations for multi-ribbed composite wall on seismic response and damage mechanism affected by the interaction between loess subsoil and structure, the shake table tests are carried out for the multi-ribbed composite wall structure scaled in 1/15 considering the interaction between the subsoil and the structure as well as the rigid foundation. After the unidirectional, bidirectional and three directional EL-Centro wave and Tianjin wave are input under different intensifies, the acceleration responses are tested. Then the lateral acceleration responses considering the interaction were compared to the rigid foundation as the destruction phenomenon. And the amplify effect to earthquake waves for subsoil and that of interaction for seismic response of floors are analyzed. As a result, after earthquake waves are input, the failure model of the interaction system is cracking on subsoil, while the failure model of the multi-ribbed composite wall structure with rigid foundation is slippage across bottom joint slit. The seismic amplify effects for subsoil are related to frequency characters, intensify, and inputting to earthquake waves. The influence by the interaction for lateral dynamic response at each floor is different, and the interaction is also affected by frequency spectrum of earthquake and seismic intensify. As the interaction coefficients are close to the amplify coefficients of subsoil, the adjustment coefficients of seismic affection can be seen as the amplify coefficients of subsoil.