Vibration and noise of liquid filled pipeline is an important part of the noise of ship mechanical system. The vibration prediction of pipe is an important basis for ship acoustic design. Based on the vibration equations of the liquid pipe, the impedance matrix of components in the pipeline system is established by combing the theoretical analysis with the test result. Experiments results are carried out to verify the calculation method. The contrast results show: The results of this paper are in good agreement with both simulation results and test results. The calculation method of this paper has high accuracy and engineering application value in middle-high frequency range.