The irregularity of track and the operation of equipment makes high-speed electric multiple units (EMU) to generate complex vibration during operation, which seriously reduces riding comfort and driving safety. In view of these problems, modal analysis is carried out on car body in order to improve the dynamic response of vehicle. A finite element model for the car body of a high-speed EMU is built, three kinds of car body modal under different mass conditions are calculated, the effects of equipment hanging position and hanging point number on modal frequencies of car body analyzed, and the change ranges of modal frequencies and modal shapes are concluded. On the basis of the finite element calculation, the vehicle modal test system is built, the modal tests of the car body is performed, the difference between the simulation results and the test results is analyzed, and the validity of numerical calculation and finite element model is demonstrated. Results show that the modal frequencies of the car body meet design standards, the modal shapes have the similar variation tendency under different mass conditions, hanging position has obvious influence on the modal frequencies of under frame vertical bending and car body torsional bending, and the modal frequencies of car body increases gradually with the increase of hanging point number.