In order to further improve the earthquake safety of the tunnel portal section in soft rock of meizoseismal area, large-scale shaking table model tests are carried out for the tunnel portal section in soft rock with the secondary lining of steel fiber reinforced concrete, the secondary lining of basalt fiber-reinforced concrete and the secondary lining of reinforced concrete, relying on the tunnel engineering of Baiyunding tunnel portal section.. The experimental results show that the strength and toughness of the supporting structure are improved by using the secondary lining of fiber reinforced concrete, which can effectively improve the safety of the tunnel structure in earthquake. The safety of the tunnel structure in hard rock is controlled by the kinematic interaction. The change of the earthquake inertia force in the tunnel structure bears is very small, and the minimum safety factor greatly increases up to 71.07%, by using the fiber reinforced concrete secondary lining. Furthermore, the safety of the tunnel structure in soft rock is controlled by both the kinematic interaction and the seismic inertia interaction. It is obvious for the tunnel structure to resist its earthquake inertia force, and the minimum safety factor increases by 30.40%, with the fiber reinforced concrete secondary lining. The results can provide references for anti-seismic and fortification design of tunnel portal section in soft rock of meizoseismal area.