A large number of experimental data are dependent on the design process of traditional wire rope isolator， new product development costs are high and the testing cycle is long. In order to solve this engineering problem， firstly， the space trajectory equation of the wire rope isolator was established through the transformation of the space coordinate system， and the space curve of each core wire of the wire rope and the three-dimensional model were obtained by using Matlab and Pro/E. Secondly， ABAQUS was used to analyze and calculate the equivalent impact stiffness and impact loss factor of wire rope vibration isolators with different structural parameters， and the simulation results are verified by impact test. Results show that the section diameter has a significant influence on the equivalent impact stiffness； and the spiral diameter has a significant influence on the impact loss factor. The equivalent impact stiffness and impact loss factor have nonlinear relationships with structure parameters. The error between the test data and the simulation result does not exceed 10%. Conclusions can provide theoretical guidance for the design and manufacture of shock-resistant wire rope isolators.